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Fundamental Neuroscience Unknowns

  • What is the mechanism of anesthesia?
  • What is consciousness?
  • What is sleep?
  • What is pain?
  • What is the trigger between acute and chronic pain?
  • Fundamental mechanisms of drug action during anesthesia/surgery
  • How do we safely anesthetize kids?
  • How do we safely anesthetize adults?
  • What are the long-term effects of surgery?
  • What is the mechanism underlying perioperative cognitive dysfunction?
  • What are the mechanisms and interventions possible for postoperative delirium?
  • Can specific anesthesia techniques influence (positive influence or protect from) long-term sequelae of surgery?

Immune and Metabolic Consequences of Trauma, Surgery and Critical Care

  • What is the role of mitochondrial dysfunction in perioperative outcomes?
  • What is the best way to control/manage robust inflammatory response to surgery?
  • What non-traditional adjuvants (botox/acupuncture/non-opioids) are effective and should be included in practice?
  • What are the mechanisms underlying organ dysfunction in trauma/burn and intervention targets?
  • What are key mechanisms for prevention/treatment of sepsis?
  • What is the best way to monitor brain function in an anesthetized patient?
  • What are the long-term risks to having surgery and anesthesia (early CAD)?
  • What is on the horizon for coagulation biology and where would this be helpful in the OR?
  • What is the best strategy for perioperative transfusions?
  • What is the best way to assess adequate perfusion during anesthesia?
  • What are new ways of understanding fluid biology during surgery?  (e.g. does "third space" really exist under stress of surgery with infusion therapy?)

Best Use of Systems-Based Practice to Enhance Patient Safety & Quality

  • How can anesthesia revolutionize rapid response teams to enhance patient safety?
  • What system changes need to be made to appropriately include postoperative analgesia with intraoperative anesthesia (regional/general combo efficiency)?
  • What practices in the OR truly affect ICU course, positive or negative?
  • What is the role of regional anesthesia (risks/benefits) in OR anesthesia and postoperative pain management?
  • How do we enhance perioperative patient safety?
  • Do we have the best preoperative risk assessment?
  • What is the safest way to manage out of OR sedation?
  • How do we risk assess patients for non-CAD illnesses (thrombosis, SIRS, etc)?
  • How can we most effectively translate knowledge/science to evidence-based anesthesia practice? 
  • What health disparities exist in anesthesia and how can we overcome such barriers in patient care?
  • What is the best way to assess patient outcome after surgery/anesthesia?
  • What are the best, and most innovative, ways of educating MD anesthesiologists for future practice in the world of health care teams?